CD44 impacts glomerular parietal epithelial cell changes in the aged mouse kidney
نویسندگان
چکیده
منابع مشابه
Glomerular parietal epithelial cells in kidney physiology
Purpose of review We have summarized recently published glomerular parietal epithelial cell (PEC) research, focusing on their roles in glomerular development and physiology, and in certain glomerular diseases. The rationale is that PECs have been largely ignored until the recent availability of cell lineage tracing studies, human and murine PEC culture systems, and potential therapeutic interve...
متن کاملChanges in glomerular parietal epithelial cells in mouse kidneys with advanced age.
Kidney aging is accompanied by characteristic changes in the glomerulus, but little is known about the effect of aging on glomerular parietal epithelial cells (PECs), nor if the characteristic glomerular changes in humans and rats also occur in very old mice. Accordingly, a descriptive analysis was undertaken in 27-mo-old C57B6 mice, considered advanced age. PEC density was significantly lower ...
متن کاملTitle : 2 Changes In Glomerular Parietal Epithelial Cells In Mouse Kidneys With Advanced Age
1 1 Title: 2 Changes In Glomerular Parietal Epithelial Cells In Mouse Kidneys With Advanced Age 3 4 Authors: 5 Sebastian S. Roeder, Ania Stefanska, Diana G. Eng, Natalya Kaverina, Maria W. Sunseri, 6 Bairbre A. McNicholas, Peter Rabinovitch, Felix B. Engel, Christoph Daniel, Kerstin 7 Amann, Julia Lichtnekert, Jeffrey W. Pippin, Stuart J. Shankland 8 9 Institutions: 10 1) Division of Nephrology...
متن کاملTranscriptional Landscape of Glomerular Parietal Epithelial Cells
Very little is known about the function of glomerular parietal epithelial cells (PECs). In this study, we performed genome-wide expression analysis on PEC-enriched capsulated vs. PEC-deprived decapsulated rat glomeruli to determine the transcriptional state of PECs under normal conditions. We identified hundreds of differentially expressed genes that mapped to distinct biologic modules includin...
متن کاملNew Insights into Glomerular Parietal Epithelial Cell Activation and Its Signaling Pathways in Glomerular Diseases
The glomerular parietal epithelial cells (PECs) have aroused an increasing attention recently. The proliferation of PECs is the main feature of crescentic glomerulonephritis; besides that, in the past decade, PEC activation has been identified in several types of noninflammatory glomerulonephropathies, such as focal segmental glomerulosclerosis, diabetic glomerulopathy, and membranous nephropat...
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ژورنال
عنوان ژورنال: Physiological Reports
سال: 2020
ISSN: 2051-817X,2051-817X
DOI: 10.14814/phy2.14487